Infectious Mononucleosis(THE KISSING DISEASE)
EBV is transmitted via intimate contact with body secretions, primarily oropharyngeal secretions. EBV infects the B cells in the oropharyngeal epithelium. The organism may also be shed from the uterine cervix, implicating the role of genital transmission in some cases. On rare occasion, EBV is spread via blood transfusion.
Circulating B cells spread the infection throughout the entire reticular endothelial system (liver, spleen, and peripheral lymph nodes). EBV infection of B lymphocytes results in a humoral and cellular response to the virus.early signs include fever, lymphadenopathy, pharyngitis, rash, and/or periorbital edema.
Relative bradycardia has been described in some patients with EBV mononucleosis, but it is not a constant finding.
Later physical findings include hepatomegaly, palatal petechiae, jaundice, uvular edema, splenomegaly, and, rarely (1-2%), findings associated with splenic rupture
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